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  基本信息
  • 姓      名:苟德明
  • 职      称: 教授
  • 职      位:
  • 所  属 系:生物技术系
  • 办公地点:西丽A6/322
  • 办公电话:0755-26527848
  • 邮      箱:dmgou@szu.edu.cn
  • 工作职责:教学,科研
  个人简介
1986-1996年,在西北农林科技大学先后获得学士、硕士及博士学位。曾在武汉大学(1997-1999)、香港理工大学(1999-2011)和美国Oklahoma州立大学(OSU,2012-2014)做博士后/研究员。历任武汉大学生命科学学院副教授,OSU动物医学院研究型副教授,芝加哥Illinois大学(UIC)医学部终身制助理教授。2011年回国至今,现为深圳大学生命与海洋科学学院教授,深圳市“鹏城学者”特聘教授,深圳市地方级领军人才,深圳大学领军人才,深圳大学优秀学者,深圳大学优秀研究生导师,国家自然科学基金委医学部一、二审专家,美国心脏学会会员, 美国生理学会会员, 中国生理学会会员,Scientific Reports杂志编委。2018年11月至今,任深圳大学血管病研究中心主任。先后主持国家自然科学基金重点培育项目1项、主持国自然面上项目3项、参加科技部重点专项1项,参加国家“973”重大研发项目1项、参加农业部转基因专项1项、主持深圳市科创委重点研发项目3项、主持深圳大学多学科交叉创新团队项目1项,到账总经费上千万,发表论文84篇(H因子24),授权发明专利5项。

当前主要研究方向:
1. 肺动脉高压发病机制及药物治疗研究:重点研究非编码RNA(lncRNA和miRNA)在肺动脉平滑肌细胞的异常增殖/迁移、肺血管重塑及肺高压发生发展过程中的表达、调控、功能及作用机制,筛选有潜力的治疗肺高压的新靶点,并利用中药来源的单体化合物进行肺高压的预防或治疗研究。
2. 肿瘤液体活检技术的研究:利用课题组领先的循环miRNA直扩PCR技术和正在完善的血浆甲基化cfDNA捕获及测序分析平台,建立针对肺癌、乳腺癌和结直肠癌等常见肿瘤的早期诊断、预后评估和疗效检测的新方法。

发表论文情况:
1. Niu Y, Su M, Wu Y, Fu L, Kang K, Li Q, Li L, Hui G, Li F* and Gou D*, Circulating plasma microRNAs as potential biomarkers of non-small cell lung cancer obtained by high-throughput real-time PCR profiling, Cancer Epidemiol Biomarkers Prev, 2019, 28(2):327-336.
2. Qian Z*, Li Y, Yang H, Chen J, Li X and Gou D*. PDGFBB promotes proliferation and migration via regulating miR-1181/STAT3 axis in human pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2018; 315(6):L965-L976.
3. Li Y, Li L, Qian Z, Lin B, Chen J, Luo Y, Qu J, Raj JU, Gou D*. Phosphatidylinositol 3-Kinase–DNA Methyltransferase 1–miR-1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor–Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells. Journal of the American Heart Association. 2018; 7(6): e007572.
4. Chen J, Guo J, Cui X, Dai Y, Tang Z, Qu J, Raj JU, Hu Q, Gou D*. Long Non-Coding RNA LnRPT is Regulated by PDGF-BB and Modulates Proliferation of Pulmonary Artery Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018;58(2):181-193.
5. Ma L, Qiu H, Chen Z, Li L, Zeng Y, Luo J, Gou D*. miR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PGC-1beta. J Anim Sci Biotechnol. 2018 Jun 18;9:48. doi: 10.1186/s40104-018-0262-0.
6. Tang Z, Qiu H, Liu N, Luo L, Zhong J, Kang K, Li L, Gou D*. miR-34b Modulates Skeletal Muscle Cell Proliferation and Differentiation. Journal of Cellular Biochemistry; 2017;118(12):4285-4295.
7. Qian Z*, Li Y, Chen J, Li X, Gou D*. MiR-4632 mediates PDGFBB-induced proliferation and anti-apoptosis of human pulmonary artery smooth muscle cells via targeting cJUN. Am J Physiol Cell Physiol. 2017;313(4):C380-C391.
8. Chen J, Cui X, Li L, Qu J, Raj JU, Gou D*. MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Physiol Rep. 2017;5(18): e13441.
9. Tang Z, Liu N, Luo L, Kang K, Li L, Ni R, Qiu H*, Gou D*. microRNA-17-92 regulates the transcription factor E2F3b during myogenesis in vitro and in vivo. Int J Mol Sci. 2017;18(4); pii: E727.
10. Qiu H, Zhong J, Luo L, Tang Z, Liu N, Kang N, Li L, Gou D*. Regulatory axis of miR-195/497 and HMGA1–Id3 governs muscle cell proliferation and differentiation. Int J Biol Sci. 2017;13(2):157-166.
11. Niu N, Wu Y, Huang J, Li Q, Kang K, Qu J, Li F* and Gou D*. Identification of reference genes for circulating microRNA analysis in colorectal cancer. Sci Rep. 2016; 6:35611.
12. Chen, J; Cui X; Qian Z; Li Y, Kang K, Qu J, Li L*, Gou D*. Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cell. BMC Genomics. 2016; 17(1):781.
13. Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, Qu J, Peng W, Liu L, Li L* and Gou D*: MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Cell Death and Differentiation. 2016;23(10):1658-1669.
14. Qian Z, Zhang L, Chen J, Li Y, Kang K, Qu J, Wang Z, Zhai Y, Li L, Gou D*. MiR-328 targeting PIM-1 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in PDGFBB signaling pathway. Oncotarget. 2016;7(34):54998-55011.
15. Zeng Y, Zhang X, Kang K, Chen J, Wu Z, Huang J, Lu W, Chen Y, Zhang J, Wang Z, Zhai Y, Qu J, Ramchandran R, Raj JU, Wang J*, Gou D*. MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells. Sci Rep. 2016; 6:24900.
16. He J, Huang L, Qiu H, Li J, Luo L, Li Y, Tian S*, Kang K, Luo J, Liu L, Gou D*. A new design of a lentiviral shRNA vector with inducible co-expression of ARGONAUTE 2 for enhancing gene silencing efficiency. Cell Biosci. 2015 8;5:67
17. Qian Z, Wu Z, Huang L, Qiu H, Wang L, Li L, Yao L, Kang K, Qu J, Wu Y, Luo J, Liu J, Yang L, Yang W, Gou D*. Mulberry fruit prevents LPS-induced NF-B/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice, Sci Rep. 2015;5:17348.
18. Niu Y, Zhang L, Qiu H, Wu Y, Wang Z, Zai Y, Liu L, Qu J, Kang K*, Gou D*. An improved method for detecting circulating microRNA with S-Poly(T) Plus real-time PCR. Sci Rep. 2015;5:15100;
19. Zeng Y, Liu H, Kang K, Wang Z, Hui G, Zhang X, Zhong J, Peng W, Ramchandran W, Raj JU, Gou D*. Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells. Sci Rep. 2015; 5:12098
20. Zeng Y, Wang Y, Wu Z, Kang K, Peng X, Peng W, Qu J, Liu L, Raj JU, Gou D*. MicroRNA-9 enhances the transactivation of nuclear factor of activated T cells by targeting KPNB1 and DYRK1B. Am J Physiol Cell Physiol. 2015; 308(9):C720-728.
21. Zeng Y, Pan Y, Long H, Kang K, Wu Y, Hui G, Peng W, Gou D*. MiR-20a regulates PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells. FEBS Letters, 2014; 588(24): 4677-1685.
22. Li L, Wang L, Wu Z, Yao L, Wu Y, Huang L, Liu K, Zhou X, Gou D*. Anthocyanin-rich fractions from red raspberries attenuate inflammation in bothRAW264.7 macrophages and a mouse model of colitis. Sci Rep. 2014; 4:6234.
23. Kang K, Peng X, Zhang X, Wang Y, Zhang L, Gao L, Weng T, Zhang H, Ramchandran R, Raj JU, Gou D*, Liu L*. MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J Biol Chem. 2013; 288(35):25414-25427.

主持或参加科研项目情况(按时间倒序排序):
1. 国家自然科学基金委重大研究计划培育项目,91739109,长非编码RNA-VELRP促进肺动脉平滑肌细胞增殖和肺血管迁移的功能及机制,2018/1-2020/12,72万,在研,主持。
2. 国家自然科学基金面上项目,81570046,PDGF通过下调miR-1281诱发肺动脉高压形成的分子机制,2016/1-2019/12,55万,在研,主持。
3. 深圳市基础学科布局项目,JCYJ20150729104027220,成纤维细胞全基因组三维转录调控网络研究,2016/10-2018/12,300万,已结题,主持。
4. 国家重点研发计划(重大慢性) 环境与遗传因素对慢阻肺临床进程的影响研究,2016YFC1304003,2016/9-2020/12,20万,在研,参加。
5. 深圳大学交叉学科创新团队项目,非编码RNA在表观遗传修饰中的表达、调控及功能研究,2015/9-2020/8,300万,在研,主持。
6. 国家自然科学基金面上项目,81370151,低氧下调miR-223在肺动脉高压形成中的作用及分子机制研究,2014/1-2017/12,70万,已结题,主持。
7. 国家自然科学基金面上项目,81170047,miR-351/-322通过抑制BMPR2在缺氧性肺动脉高压中的作用及分子机制研究,2012/1-15/12,60万,已结题,主持。
8. 深圳市科创委技术开发项目,CXZZ20140828163951592,肺癌循环非编码小RNA生物标记物的筛查及其临床直扩试剂盒的开发与应用,2015/1-2016/12,150万,已结题,主持。
9. 深圳市海外高层次人才创新创业专项资金项目,YFZZ20111009,不同病因肺动脉高压血清microRNA标记物的筛选、作用机理及治疗效用研究,2012/11-2016/12,160万,已结题,主持。
10. 深圳市南山区技术攻关项目,KC2013JSJS0020A,高效有保证的RNAi技术,2013/7-2015/6,100万,已结题,主持。
11. 国家973项目子课题,2012CB124701, 肌纤维分化与肌纤维类型转化的机理研究,2014/6-2017/5,85万,已结题,参加。
12. 农业部转基因专项,2014ZX08009-051B,奶山羊乳品质性状关键基因重要调控元件筛选及功能验证,2014/1-2016/12,40万,已结题,参加。
13. 深圳市基础研究重点项目,ZC201006010725A, miR-20a调控胎肺发育的分子机制,2010-2012,20万,已结题,主持。
  近期发表的论文
  • 1、 Niu N, Wu Y, Huang J, Li Q, Kang K, Qu J, Li F and Gou D*. Identification of reference genes for circulating microRNA analysis in colorectal cancer. Sci Rep.  2016; Oct 19;6:35611.    SCI  2019-06-11
  • 2、Qian Z, Zhang L, Chen J, Li Y, Kang K, Qu J, Wang Z, Zhai Y, Li L, Gou D*. MiR-328 targeting PIM-1 inhibits proliferation and migration of pulmonary arterial smooth muscle cells in PDGFBB signaling pathway. Oncotarget.    SCI  2019-06-11
  • 3、Qiu H, Liu N, Luo L, Zhong J, Tang Z, Kang K, Qu J, Peng W, Liu L, Li L and Gou D*: MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis. Cell Death and Differentiation. 2016  Oct;23(10):1658-69.    SCI  2019-06-11
  • 4、Kang K, Peng X, Zhang X, Wang Y, Zhang L, Gao L, Weng T, Zhang H, Ramchandran R, Raj JU, Gou D*, Liu L*. MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J Biol Chem. 2013; 288(35):25414-25427    SCI  2019-03-04
  • 5、Li L, Wang L, Wu Z, Yao L, Wu Y, Huang L, Liu K, Zhou X, Gou D*. Anthocyanin-rich fractions from red raspberries attenuate inflammation in bothRAW264.7 macrophages and a mouse model of colitis. Sci Rep. 2014; 4:6234.    SCI  2019-03-04